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cardiac-amyloidosis cardiac-amyloidosis

Proven results
with Attruby

Ken, taking Attruby for ATTR-CM,
and his care partner, Mary.

What Is Attruby?
How Attruby Works
Clinical Study
Results
Side Effects

Attruby delivered rapid and sustained results in wild-type info Wild-type refers to a form of ATTR-cardiac amyloidosis that people develop as they age. and hereditary info A characteristic or trait that is passed down through your family in your genes.
ATTR-cardiac amyloidosis (ATTR-CM)

In a 30-month clinical study, info All medicines approved for use must undergo rigorous testing led by healthcare professionals and scientists to show that the medicine works. people treated with Attruby did significantly better than those not taking Attruby
(placebo info A placebo is a pill that has no actual treatment in it but is given to a person so they assume they are receiving real medicine. ). The results were based on a combined measure of survival and hospitalizations due to heart issues.
3 months

Impact on survival and hospitalizations due to heart issues was observed as early as 3 months.

When comparing results in people treated with and without Attruby at 30 months,
people taking Attruby experienced:

42 percent

42% more likely to live longer and have fewer repeat hospitalizations due to heart issues

These results come from a follow-up study.

50 percent

Less likely to be hospitalized due to heart issues (an average of 0.3 vs 0.6 visits per year)

better-qol

A better health-related quality of life*†

These results come from a follow-up study.

Impact on health-related quality of life was first observed after 3 months.†

When comparing health-related quality of life measures in people treated with and without Attruby at 30 months, people treated with Attruby reported better results:

  • Improved symptoms

    Symptoms

    Reduced shortness of breath and fatigue, info Fatigue describes an overall feeling of tiredness or lack of energy. It’s not the same as being drowsy or sleepy. When you're fatigued, you lack energy to do daily activities. as well as less swelling in the legs, ankles, and feet.
  • Improved physical abilities

    Physical abilities

    Ability to walk 1 block on level ground and climbing up a short flight of stairs without stopping.‡

  • Improved social engagement

    Social engagement

    People were able to experience better overall enjoyment of life, such as visiting with family or friends.§

*The treatment effect of Attruby on health status was assessed using the Kansas City Cardiomyopathy Questionnaire-Overall Summary
(KCCQ-OS) score composed of the physical limitation, symptom, social limitation, quality of life, and self-efficacy domains, respectively.

†At the end of the 30-month study of adults with ATTR-CM, on average, people taking and not taking Attruby experienced a decline in their KCCQ-OS, a measure of health-related quality of life.

‡Other physical improvements included ability to do household chores and showering or bathing independently.

§This also included better engagement with their hobbies or enjoying intimate relationships.

What Is Attruby?
How Attruby Works
Clinical Study
Results
Side Effects
Next: Side Effects

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Indication and Important Safety Information for Attruby

IMPORTANT SAFETY INFORMATION

Before taking Attruby, tell your healthcare provider about all your medical conditions, including if you:

  • are pregnant or plan to become pregnant

  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Attruby?
The most common side effects of Attruby were mild and include:

  • diarrhea

  • stomach-area (abdominal) pain

These are not all of the possible side effects of Attruby. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is Attruby® (acoramidis)?

Attruby is a prescription medicine used to treat adults with a disease that affects the heart muscle called cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM), to reduce death and hospitalization related to heart problems.

It is not known if Attruby is safe and effective in children.

For the Full Prescribing Information and Patient Information for Attruby, visit Attruby.com/PI