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cardiac-amyloidosis cardiac-amyloidosis

ATTR-cardiac amyloidosis
(ATTR-CM) is a serious and progressive
heart condition

Actor portrayals.

Symptoms
About ATTR-Cardiac Amyloidosis
Diagnosis and Management

ATTR-CM symptoms are often overlooked or misdiagnosed

Because the symptoms associated with ATTR-CM are shared with other heart conditions, a formal diagnosis can take years.

Symptoms may include:
  • Shortness of breathShortness of breath
  • Swelling in legsSwelling in legs
    or feet
  • Digestive problemsDigestive problems
  • Tiredness or weaknessTiredness or weakness
  • Irregular heartbeatIrregular heartbeat
  • Nerve painNerve pain
Did you
know?
APPROXIMATELY
60%
of people diagnosed with ATTR-CM
experience carpal tunnel syndrome
info This is a common condition where nerves in the wrist become pinched, causing symptoms like numbness, tingling, and pain.
UP TO
40%
of people also experience spinal stenosis,
info Spinal stenosis is a condition where the space inside the spine narrows, which puts pressure on the spinal cord and nerves. Some people don’t have any symptoms, while others may experience pain, weakness, and numbness that worsens over time.
when the
space inside of the backbone is too small, causing
pain, tingling, numbness, and muscle weakness.

Untreated ATTR-CM can stop you from living life the way you want

  • symptoms1
    Missing out on
    important life
    moments
  • symptoms1
    Having trouble
    with daily tasks
  • symptoms1
    Giving up
    activities you
    enjoy

Without intervention, issues become serious

  • symptoms1
    Heart failure
    info Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly.
  • symptoms1
    More hospital
    visits
  • symptoms1
    Early death

ATTR-cardiac amyloidosis happens
when TTR
info Transthyretin, pronounced "trans-thy-retin," or TTR is an important protein that helps transport thyroxine, a thyroid hormone, and retinol (vitamin A) in your body.
becomes unstable
and misfolds

Understanding TTR will help you
understand ATTR-cardiac amyloidosis

The TTR protein is an important protein that helps transport
the hormone thyroxine (which regulates your metabolism)
and retinol (vitamin A) in your body; hence the name
TTR: “trans-thy-retin”

There are 2 forms of ATTR-cardiac amyloidosis

  • 1
    Wild-type, caused by natural aging
  • 2
    Hereditary, when the condition is passed down
    through the family
  • icon
    Stable TTR is healthy TTR

    TTR is made up of 4 small proteins held tightly together through strong bonds.

  • icon
    Unstable TTR creates amyloid fibrils
    info When transthyretin (TTR) becomes unstable, it breaks down and reforms into abnormal proteins called amyloid fibrils.

    When the bonds become unstable, TTR breaks down into abnormal proteins called amyloid fibrils,
    which then build up in the body, causing damage.

  • icon
    Amyloid fibrils are trouble
    The buildup of amyloid fibrils thickens the walls of the heart. That means the heart cannot pump blood
    properly, causing the symptoms of heart failure
    info Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly.
    you may be familiar with, such as breathlessness,
    fatigue, and swelling of the legs.

The more stable your TTR, the less likely it will break down and cause trouble.

Did you
know?
A simple blood test can measure stable TTR levels
It’s called a serum TTR test or prealbumin blood test.
info This test measures transthyretin (TTR) levels, also known as prealbumin. It measures overall health status. The higher your number is on the scale, the more stable TTR there is in your body.
Talk to your doctor
about testing your TTR levels.
circles

Diagnosis accompanied by effective management of ATTR-cardiac amyloidosis
may help you:

  • icon Focus on maintaining heart health for as
    long as possible
  • icon Experience fewer hospital visits
  • icon Find ways to keep up with some of the
    activities you enjoy
  • icon Take steps to maintain your quality of life

Track your well-being

Taking notes about your physical and mental health can help
you build a clearer picture of your overall well-being. Share your
insights with your care partner and doctor.

Download Wellness Journal
Symptoms
About ATTR-Cardiac Amyloidosis
Diagnosis and Management
Symptoms icon

ATTR-CM symptoms are often overlooked or misdiagnosed

Because the symptoms associated with ATTR-CM are shared with other heart conditions, a formal diagnosis can take years.

Symptoms may include:
  • Shortness of breathShortness of breath
  • Swelling in legsSwelling in legs
    or feet
  • Digestive problemsDigestive problems
  • Tiredness or weaknessTiredness or weakness
  • Irregular heartbeatIrregular heartbeat
  • Nerve painNerve pain
Did you know?
APPROXIMATELY
60%
of people diagnosed with
ATTR-CM experience carpal tunnel syndrome info This is a common condition where nerves in the wrist become pinched, causing symptoms like numbness, tingling, and pain.
UP TO
40%
of people also experience spinal stenosis, info Spinal stenosis is a condition where the space inside the spine narrows, which puts pressure on the spinal cord and nerves. Some people don’t have any symptoms, while others may experience pain, weakness, and numbness that worsens over time. when the space inside of the backbone is too small, causing pain, tingling, numbness, and muscle weakness.

Untreated ATTR-CM can stop you from living life the way
you want

  • symptoms1
    Missing out on important
    life moments
  • symptoms1
    Having trouble with
    daily tasks
  • symptoms1
    Giving up activities
    you enjoy

Without intervention, issues become serious

  • symptoms1
    Heart failure info Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly.
  • symptoms1
    More hospital visits
  • symptoms1
    Early death
About ATTR-Cardiac Amyloidosis (ATTR-CM) icon

ATTR-cardiac amyloidosis (ATTR-CM) happens when TTR info Transthyretin, pronounced "trans-thy-retin," or TTR is an important protein that helps transport thyroxine, a thyroid hormone, and retinol (vitamin A) in your body. becomes unstable and misfolds

There are 2 forms of ATTR-cardiac amyloidosis (ATTR-CM)

  • 1
    Wild-type, caused by natural aging
  • 2
    Hereditary, when the condition is passed down through the family

Understanding TTR will help you understand
ATTR-cardiac amyloidosis
(ATTR-CM)

The TTR protein is an important protein that helps transport the hormone thyroxine (which regulates your metabolism) and retinol (vitamin A) in your body; hence the name TTR:
“trans-thy-retin”
  • Stable TTR is healthy TTR
    icon

    TTR is made up of 4 small proteins held tightly together through strong bonds.

  • Unstable TTR creates amyloid fibrils info When transthyretin (TTR) becomes unstable, it breaks down and reforms into abnormal proteins called amyloid fibrils.
    icon

    When the bonds become unstable, TTR breaks down into abnormal proteins called amyloid fibrils, which then build up in the body, causing damage.

  • Amyloid fibrils are trouble
    icon The buildup of amyloid fibrils thickens the walls of the heart. That means the heart cannot pump blood properly, causing the symptoms of heart failure info Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly. you may be familiar with, such as breathlessness, fatigue, and swelling of the legs.

The more stable your TTR, the less likely it will break down and cause trouble.

Did you know?
A simple blood test can measure stable TTR levels
It’s called a serum TTR test or prealbumin blood test. info This test measures transthyretin (TTR) levels, also known as prealbumin. It measures overall health status. The higher your number is on the scale, the more stable TTR there is in your body. Talk to your doctor about testing your TTR levels.
circles
Diagnosis and Management icon

Diagnosis accompanied by effective management of ATTR-cardiac amyloidosis(ATTR-CM)
may help you:

  • icon Focus on maintaining heart health for as long as possible
  • icon Experience fewer hospital visits
  • icon Find ways to keep up with some of the activities you enjoy
  • icon Take steps to maintain your quality of life

Track your well-being

Taking notes about your physical and mental health can help you build a clearer picture of your overall well-being. Share your insights with your care partner and doctor.

Download Wellness Journal
Next: How can Attruby help?

What is Attruby?

Attruby is a prescription medicine used to treat adults with a disease that affects the heart muscle called cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM), to reduce death and hospitalization related to heart problems.

It is not known if Attruby is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Before taking Attruby, tell your healthcare provider about all your medical conditions, including if you:

  • are pregnant or plan to become pregnant

  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Attruby?
The most common side effects of Attruby were mild and include:

  • diarrhea

  • stomach-area (abdominal) pain

These are not all of the possible side effects of Attruby.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Important Safety Information throughout and accompanying Important Facts Sheet for Attruby. For the Full Prescribing Information and Patient Information for Attruby, visit Attruby.com/PI.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is Attruby™ (acoramidis)?

Attruby is a prescription medicine used to treat adults with a disease that affects the heart muscle called cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM), to reduce death and hospitalization related to heart problems.

It is not known if Attruby is safe and effective
in children.

IMPORTANT SAFETY INFORMATION

Before taking Attruby, tell your healthcare provider about all your medical conditions, including if you:

  • are pregnant or plan to become pregnant

  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Attruby?
The most common side effects of Attruby were mild and include:

  • diarrhea

  • stomach-area (abdominal) pain

These are not all of the possible side effects of Attruby.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Important Safety Information throughout and accompanying Important Facts Sheet for Attruby. For the Full Prescribing Information and Patient Information for Attruby, visit Attruby.com/PI.

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