Get the latest on ATTR-cardiac amyloidosis (ATTR-CM) and Attruby, including:

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Proven results
with Attruby

Actor portrayals.

Understanding how Attruby was studied

How effective and safe Attruby was for people with
ATTR-cardiac amyloidosis (ATTR-CM) was assessed in a clinical study.

See Results

611

People participated

This study is one of the largest for
ATTR-CM
77

Average age

The average age of people in the study
with wild-type Wild-type refers to a form of ATTR-cardiac amyloidosis that people develop as they age. or hereditary A characteristic or trait that is passed down through your family in your genes. ATTR-CM
was 77 years old
409

People took Attruby

Out of 611 people, 409 took Attruby and 202 received placebo A placebo is a pill that has no actual treatment in it but is given to a person so they assume they are receiving real medicine.
30

Months

The study lasted for 30 months
90%

Were male

10%

Were female
- 10% had hereditary ATTR-CM
- 58% had a history of atrial fibrillation A heart condition that causes an irregular and sometimes abnormally fast heart rate.
- 19% had a permanent pacemaker

Primary measures, which helped determine how well Attruby worked over the 30-month study, included a combined measure of:

Additional assessments included:

Blood test measurements Your doctor may order blood tests so they can better understand the health of your heart in ATTR-cardiac amyloidosis. The most common tests are a serum TTR test (also known as a prealbumin blood test) and NT-proBNP test, which is a measure of heart health. ; when your
heart isn’t working properly, your body has a
biochemical response which can be assessed

The most common tests are:
- TTR or prealbumin blood test This test measures transthyretin (TTR) levels, also known as prealbumin. It measures overall health status. The higher your number is on the scale, the more stable TTR there is in your body.
- NT-proBNP
Health-related quality of life, which was
measured using a questionnaire specifically
designed for people who have cardiomyopathy

Quality of life was measured using a questionnaire known
as the Kansas City Cardiomyopathy Questionnaire (KCCQ).
It consists of 23 questions that help your doctor get a clearer picture of your quality of life by reviewing the frequency and burden of symptoms, and how you are doing physically
and emotionally.
Walking distance in 6 minutes, which measures heart function and exercise capacity

How far a person could walk at the beginning of the study
was compared with how far they could walk after 30 months
of treatment.