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cardiac-amyloidosis cardiac-amyloidosis

ATTR-cardiac amyloidosis
(ATTR-CM) is a serious,
progressive heart condition

Actor portrayals.

Symptoms
About ATTR-CM
Diagnosis and Management

ATTR-CM happens when TTR
info Transthyretin, pronounced "trans-thy-retin," or TTR is an important protein that helps transport thyroxine, a thyroid hormone, and retinol (vitamin A) in your body.
becomes
unstable and misfolds

Understanding TTR will help you understand
ATTR-CM

The TTR protein is an important protein that helps transport
the hormone thyroxine (which regulates your metabolism)
and retinol (vitamin A) in your body; hence the name
TTR: “trans-thy-retin”

There are 2 forms of ATTR-CM

  • 1
    Wild-type, caused by natural aging
  • 2
    Hereditary, when the condition is passed down
    through the family
  • icon
    Stable TTR is healthy TTR

    TTR is made up of 4 small proteins held tightly together through strong bonds.

  • icon
    Unstable TTR creates amyloid fibrils
    info When transthyretin (TTR) becomes unstable, it breaks down and reforms into abnormal proteins called amyloid fibrils.

    When the bonds become unstable, TTR breaks down into abnormal proteins called amyloid fibrils,
    which then build up in the body, causing damage.

  • icon
    Amyloid fibrils are trouble
    The buildup of amyloid fibrils thickens the walls of the heart. That means the heart cannot pump blood
    properly, causing the symptoms of heart failure
    info Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly.
    you may be familiar with, such as breathlessness,
    fatigue, and swelling of the legs.

The more stable your TTR, the less likely it will break down and cause trouble.

Did you
know?
A simple blood test can measure stable TTR levels
It’s called a serum TTR test or prealbumin blood test.
info This test measures transthyretin (TTR) levels, also known as prealbumin. It measures overall health status. The higher your number is on the scale, the more stable TTR there is in your body.
Talk to your doctor
about testing your TTR levels.
circles
Symptoms
About ATTR-CM
Diagnosis and Management
Next: How can Attruby help?

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Indication and Important Safety Information for Attruby

IMPORTANT SAFETY INFORMATION

Before taking Attruby, tell your healthcare provider about all your medical conditions, including if you:

  • are pregnant or plan to become pregnant

  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Attruby?
The most common side effects of Attruby were mild and include:

  • diarrhea

  • stomach-area (abdominal) pain

These are not all of the possible side effects of Attruby.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is Attruby® (acoramidis)?

Attruby is a prescription medicine used to treat adults with a disease that affects the heart muscle called cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM), to reduce death and hospitalization related to heart problems.

It is not known if Attruby is safe and effective in children.

For the Full Prescribing Information and Patient Information for Attruby, visit Attruby.com/PI.