ATTR-cardiac amyloidosis
(ATTR-CM) is a serious,
progressive heart condition

Actor portrayals.

Symptoms

About ATTR-CM

Diagnosis and Management

ATTR-CM symptoms are often overlooked or misdiagnosed

Because the symptoms associated with ATTR-CM are shared with other heart conditions, a formal diagnosis can take years.

Symptoms may include:

Shortness of breath
Swelling in legs
or feet
Digestive problems
Tiredness or weakness
Irregular heartbeat
Nerve pain

Did you
know?

APPROXIMATELY

60%

of people diagnosed with ATTR-CM
experience carpal tunnel syndrome

UP TO

40%

of people also experience spinal stenosis, when the
space inside of the backbone is too small, causing
pain, tingling, numbness, and muscle weakness.

Untreated ATTR-CM can stop you from living life the way you want

Missing out on
important life
moments
Having trouble
with daily tasks
Giving up
activities you
enjoy

Without intervention, issues become serious

Heart failure
Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly.
More hospital
visits
Early death

ATTR-CM happens when TTR
Transthyretin, pronounced "trans-thy-retin," or TTR is an important protein that helps transport thyroxine, a thyroid hormone, and retinol (vitamin A) in your body.
becomes
unstable and misfolds

Understanding TTR will help you understand
ATTR-CM

The TTR protein is an important protein that helps transport
the hormone thyroxine (which regulates your metabolism)
and retinol (vitamin A) in your body; hence the name
TTR: “trans-thy-retin”

There are 2 forms of ATTR-CM

1
Wild-type, caused by natural aging
2
Hereditary, when the condition is passed down
through the family

Stable TTR is healthy TTR

TTR is made up of 4 small proteins held tightly together through strong bonds.
Unstable TTR creates amyloid fibrils
When transthyretin (TTR) becomes unstable, it breaks down and reforms into abnormal proteins called amyloid fibrils.

When the bonds become unstable, TTR breaks down into abnormal proteins called amyloid fibrils,
which then build up in the body, causing damage.
Amyloid fibrils are trouble

The buildup of amyloid fibrils thickens the walls of the heart. That means the heart cannot pump blood
properly, causing the symptoms of heart failure
Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly.
you may be familiar with, such as breathlessness,
fatigue, and swelling of the legs.

The more stable your TTR, the less likely it will break down and cause trouble.

Did you
know?

A simple blood test can measure stable TTR levels

It’s called a serum TTR test or prealbumin blood test. Talk to your doctor
about testing your TTR levels.

Diagnosis accompanied by effective management of ATTR-CM may help you:

Focus on maintaining heart health for as
long as possible
Experience fewer hospital visits
Find ways to keep up with some of the
activities you enjoy
Take steps to maintain your health-related quality of life

Track your well-being

Taking notes about your physical and mental health can help
you build a clearer picture of your overall well-being. Share your
insights with your care partner and doctor.

Download Wellness Journal

Symptoms

About ATTR-CM

Diagnosis and Management

ATTR-CM symptoms are often overlooked or misdiagnosed

Because the symptoms associated with ATTR-CM are shared with other heart conditions, a formal diagnosis can take years.

Symptoms may include:

Shortness of breath
Swelling in legs
or feet
Digestive problems
Tiredness or weakness
Irregular heartbeat
Nerve pain

Did you know?

APPROXIMATELY

60%

of people diagnosed with
ATTR-CM experience carpal tunnel syndrome

UP TO

40%

of people also experience spinal stenosis,

when the space inside of the backbone is too small, causing pain, tingling, numbness, and muscle weakness.

Untreated ATTR-CM can stop you from living life the way
you want

Missing out on important
life moments
Having trouble with
daily tasks
Giving up activities
you enjoy

Without intervention, issues become serious

Heart failure Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly.
More hospital visits
Early death

ATTR-CM happens when TTR Transthyretin, pronounced "trans-thy-retin," or TTR is an important protein that helps transport thyroxine, a thyroid hormone, and retinol (vitamin A) in your body. becomes unstable and misfolds

There are 2 forms of ATTR-CM

1
Wild-type, caused by natural aging
2
Hereditary, when the condition is passed down through the family

Understanding TTR will help you understand ATTR-CM

The TTR protein is an important protein that helps transport the hormone thyroxine (which regulates your metabolism) and retinol (vitamin A) in your body; hence the name TTR:
“trans-thy-retin”

Stable TTR is healthy TTR

TTR is made up of 4 small proteins held tightly together through strong bonds.
Unstable TTR creates amyloid fibrils When transthyretin (TTR) becomes unstable, it breaks down and reforms into abnormal proteins called amyloid fibrils.

When the bonds become unstable, TTR breaks down into abnormal proteins called amyloid fibrils, which then build up in the body, causing damage.
Amyloid fibrils are trouble
The buildup of amyloid fibrils thickens the walls of the heart. That means the heart cannot pump blood properly, causing the symptoms of heart failure Heart failure means the heart isn’t pumping as well as it should. As a result, your body isn’t getting enough of the oxygen-rich blood it needs to work properly. you may be familiar with, such as breathlessness, fatigue, and swelling of the legs.

The more stable your TTR, the less likely it will break down and cause trouble.

Did you know?

A simple blood test can measure stable TTR levels

It’s called a serum TTR test or prealbumin blood test.

Talk to your doctor about testing your TTR levels.

Diagnosis accompanied by effective management of
ATTR-CM may help you:

Focus on maintaining heart health for as long as possible
Experience fewer hospital visits
Find ways to keep up with some of the activities you enjoy
Take steps to maintain your
health-related quality of life

Track your well-being

Taking notes about your physical and mental health can help you build a clearer picture of your overall well-being. Share your insights with your care partner and doctor.

Download Wellness Journal